Breast Cancer Advice Center

Calculation of Doses- patient parameters?

The dose of Taxol in metastatic breast cancer is 135 to 175 mg/m^2 by intravenous infusion over 3 hours. Calculate the number of milligrams of the drug infused every 15 minutes to a patient measuring 60 in. in height and weighing 120 lb in the maximum dose in the dosing range is administered.

Public Comments

1. BSA = sqrt( 60 in x 120 lb / 3125 in lb mm^-4) = 1.52mm^2
   
   15min = 0.25hr
   
   175mg/m^2 x 1.52mm^2 x 0.25hr / 3hr = 22.2mg